Use an email marketing service

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people who have explicitly stated that they no longer wish to receive emails from you , or whose email address has bounced. They should be removed from your list immediately, regardless of the size of the segment.
people who have not been actively involved for a long time (e.g. about a year).
In most cases, these contacts no longer have any commercial potential, but they represent a huge risk for your deliverability . Both because these addresses could have been transformed into spam traps, and because they could harm your results.

How to find contacts based on their engagement score in GetResponse.
Here's how to find contacts who haven't opened any of the emails you've sent them inside GetResponse

If you are serious about improving your sender malta phone number list reputation and email deliverability, you should partner with a good email marketing service (or email service provider , ESP).

If you're not sure whether your current platform is the right one, check whether:

has relationships with all major Internet Service Providers;
has set up feedback loops with all major email mailbox providers;
automatically handles bounces, unsubscribes and spam complaints;
does not allow its users to upload purchased or scraped lists;
participates in all major ISP industry initiatives to prevent spam, such as MAAWG, EEC, and ESPC;